64		Wandering in Space (Windows, 2017)
62		Bionic Heart 2 (Windows, 2013)
60		Bionic Heart (Windows, 2009)
57		eden* (Windows, 2015)
56		Memory's Dogma CODE:01 (Windows, 2016)
55		Lucy: -The Eternity She Wished For- (Windows, 2016)
55		Carpe Diem: Reboot (Windows, 2017)
55		Carpe Diem (Windows, 2015)
55		World End Economica: Episode.03 (Windows, 2016)
55		Himawari: The Sunflower (Windows, 2016)
54		World End Economica: Episode.02 (Windows, 2015)
54		Space Explorers (Windows, 2017)
53		Satellite (Windows, 2018)
53		Patent9 (Windows, 2018)
53		The 25th Ward: The Silver Case (Windows, 2018)
53		Magical Girl x Hero: Lightning Angel Litona-Liliche (Windows, 2018)
53		World End Economica: Episode.01 (Windows, 2014)
53		Yakuza Kiss (Windows, 2018)
52		Dysfunctional Systems: Learning to Manage Chaos (Windows, 2013)
50		Ever17: The Out of Infinity (Windows, 2005)
50		Medical 91 (Windows, 2005)
47		Angels with Scaly Wings (Windows, 2017)
47		ACE Academy (Windows, 2016)
46		Kaori After Story (Windows, 2018)
45		Echo Tokyo: Intro (Windows, 2016)
44		Blossoms Bloom Brightest (Windows, 2017)
44		Steal My Artificial Heart (Windows, 2015)
43		2236 A.D. (Windows, 2018)
40		Xenon: Mugen no Shitai (Windows, 1997)
40		Critical Point (Windows, 1998)
40		Routes (Windows, 2003)
40		Viper V-12 (Windows, 1997)
40		Force Majeure II: The Zone (Windows, 2005)
40		Viper V-8 (Windows, 1996)

Notes: Games similar to Cyber City 2157, Games like Cyber City 2157, Sometimes You, Windows, Adventure, Cyberpunk, Dark Sci-Fi, Sci-Fi, Futuristic, Visual Novel, 1st-person, PC, Game Similarities.